ICSC 1783 - TOLUENE DIISOCYANATE (80/20 mixture of 2,4- and 2,6- isomers)

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TOLUENE DIISOCYANATE (80/20 mixture of 2,4- and 2,6- isomers)	ICSC: 1783 (November 2019)
TDI 80/20 m-Tolylidene diisocyanate

CAS #: 26471-62-5

UN #: 2078

EC Number: 247-722-4

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion as a result of decomposition when heated.	NO open flames. NO contact with water.	Use powder, carbon dioxide, water in large amounts. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Irritability. Sore throat. Cough. Headache. Nausea. Vomiting. Wheezing. Chest tightness.	Use appropriate engineering controls.	Fresh air, rest. Half-upright position. Refer immediately for medical attention.
Skin	Redness. Pain. Blisters.	Protective gloves. Protective clothing.	See Notes. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Redness. Pain.	Wear in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Irritability. Sore throat. Abdominal pain. Nausea. Vomiting.		Rinse mouth. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Special emergency response required.	According to UN GHS Criteria Fatal if inhaled Causes serious eye irritation Suspected of causing cancer Harmful to aquatic life with long lasting effects May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause respiratory irritation Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from food and feedstuffs. Separated from : see Chemical Dangers. Store only in original container. Cool. Keep in a well-ventilated room. Store in an area without drain or sewer access. Refer to the manufacturer's instructions for proper storage conditions.
PACKAGING
Do not transport with food and feedstuffs.

TOLUENE DIISOCYANATE (80/20 mixture of 2,4- and 2,6- isomers)

ICSC: 1783

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance CLEAR SLIGHTLY YELLOW SOLUTION WITH CHARACTERISTIC ODOUR. Physical dangers Chemical dangers The substance polymerizes with water and many chemicals in a hazardous way. This generates fire or explosion hazard. On combustion, forms toxic gases.	Formula: C₉H₆N₂O₂ Molecular mass: 174,16 Boiling point at 101.3kPa: 252-255°C Melting point: 4 - 10°C Relative density (water = 1): 1.22 (20°C) Vapour pressure, Pa at 20°C: 1.4 - 1.5 Octanol/water partition coefficient as log Pow: 3.43 (technical grade) Solubility in water, mg/l at 25°C: 124 Flash point: see Notes Auto-ignition temperature: 595-598°C (technical grade) Viscosity: 2.221 mm²/s at 20°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
CLEAR SLIGHTLY YELLOW SOLUTION WITH CHARACTERISTIC ODOUR.

Physical dangers

Chemical dangers
The substance polymerizes with water and many chemicals in a hazardous way. This generates fire or explosion hazard. On combustion, forms toxic gases.

Formula: C₉H₆N₂O₂
Molecular mass: 174,16
Boiling point at 101.3kPa: 252-255°C
Melting point: 4 - 10°C
Relative density (water = 1): 1.22 (20°C)
Vapour pressure, Pa at 20°C: 1.4 - 1.5
Octanol/water partition coefficient as log Pow: 3.43 (technical grade)
Solubility in water, mg/l at 25°C: 124
Flash point: see Notes
Auto-ignition temperature: 595-598°C (technical grade)
Viscosity: 2.221 mm²/s at 20°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure Serious by all routes of exposure. Effects of short-term exposure Inhalation of high concentrations may cause chemical pneumonitis and lung oedema.	Inhalation risk A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
Serious by all routes of exposure.

Effects of short-term exposure
Inhalation of high concentrations may cause chemical pneumonitis and lung oedema.

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: (inhalable fraction and vapour): 0.001 ppm as TWA; 0.005 ppm as STEL; (skin); (DSEN); (RSEN); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued. MAK: (vapour and aerosol): 0.007 mg/m³, 0.001 ppm; peak limitation category: I(1); (momentary value that should not be exceeded): 0.035 mg/m³, 0.005 ppm; pregnancy risk group: C; sensitization of respiratory tract and skin (SAH)

OCCUPATIONAL EXPOSURE LIMITS

TLV: (inhalable fraction and vapour): 0.001 ppm as TWA; 0.005 ppm as STEL; (skin); (DSEN); (RSEN); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.
MAK: (vapour and aerosol): 0.007 mg/m³, 0.001 ppm; peak limitation category: I(1); (momentary value that should not be exceeded): 0.035 mg/m³, 0.005 ppm; pregnancy risk group: C; sensitization of respiratory tract and skin (SAH)

ENVIRONMENT
The substance is harmful to aquatic organisms. The substance may cause long-term effects in the aquatic environment.

NOTES
Decomposes slowly in water or acidic solutions forming carbon disulfide and amines. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact. The odour warning when the exposure limit value is exceeded is insufficient. See ICSC 0339.

NOTES

Decomposes slowly in water or acidic solutions forming carbon disulfide and amines.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The odour warning when the exposure limit value is exceeded is insufficient.
See ICSC 0339.

ADDITIONAL INFORMATION

EC Classification

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