ICSC 1733 - 2-BUTYNE-1,4-DIOL

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2-BUTYNE-1,4-DIOL	ICSC: 1733 (November 2008)
1,4-Dihydroxy-2-butyne But-2-yne-1,4-diol 2-Butynediol 1,4-Butynediol

CAS #: 110-65-6

UN #: 2716

EC Number: 203-788-6

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Risk of explosion on contact with bases, oxidizing agents or halogens.	NO open flames.	Use water spray, alcohol-resistant foam, dry powder, carbon dioxide.

STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat. Burning sensation. Shortness of breath. Laboured breathing.	Use ventilation (not if powder).	Fresh air, rest. Half-upright position. Refer immediately for medical attention.
Skin	Redness. Pain. Skin burns.	Protective clothing. Protective gloves.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.
Eyes	Redness. Pain. Burns.	Wear face shield or eye protection in combination with breathing protection if powder.	Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Ingestion	Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal pain.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Toxic if swallowed or if inhaled Harmful in contact with skin Causes severe skin burns and eye damage May cause allergic skin reaction May cause damage to liver, kidneys and blood through prolonged or repeated exposure Harmful to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Separated from incompatible materials. See Chemical Dangers. Cool. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs.

2-BUTYNE-1,4-DIOL

ICSC: 1733

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance YELLOW SOLID IN VARIOUS FORMS. Physical dangers No data. Chemical dangers Decomposes on heating. This produces toxic and corrosive fumes. Reacts violently with anhydrides, acid chlorides, mercury salts and alkaline hydroxides or chlorides. This generates explosion hazard.	Formula: C₄H₆O₂/OHCH₂CCCH₂OH Molecular mass: 86.1 Boiling point: No boiling point at normal pressure; decomposes at >160°C Melting point: 58°C Relative density (water = 1): 1.1 Solubility in water, g/100ml at 20°C: 75 (good) Vapour pressure, Pa at 20°C: 0.2 Relative vapour density (air = 1): 3.0 Flash point: 152°C Auto-ignition temperature: 335°C Octanol/water partition coefficient as log Pow: -0.73

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW SOLID IN VARIOUS FORMS.

Physical dangers
No data.

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes. Reacts violently with anhydrides, acid chlorides, mercury salts and alkaline hydroxides or chlorides. This generates explosion hazard.

Formula: C₄H₆O₂/OHCH₂CCCH₂OH
Molecular mass: 86.1
Boiling point: No boiling point at normal pressure; decomposes at >160°C
Melting point: 58°C
Relative density (water = 1): 1.1
Solubility in water, g/100ml at 20°C: 75 (good)
Vapour pressure, Pa at 20°C: 0.2
Relative vapour density (air = 1): 3.0
Flash point: 152°C
Auto-ignition temperature: 335°C
Octanol/water partition coefficient as log Pow: -0.73

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Serious local effects by all routes of exposure. Effects of short-term exposure Corrosive. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Medical observation is indicated.	Inhalation risk A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in anaemia. The substance may have effects on the kidneys and liver. This may result in tissue lesions. Repeated or prolonged contact may cause skin sensitization.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Serious local effects by all routes of exposure.

Effects of short-term exposure
Corrosive. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in anaemia. The substance may have effects on the kidneys and liver. This may result in tissue lesions. Repeated or prolonged contact may cause skin sensitization.

OCCUPATIONAL EXPOSURE LIMITS
MAK: 0.36 mg/m³, 0.1 ppm; peak limitation category: I(1); skin absorption (H); sensitization of skin (SH); pregnancy risk group: C. EU-OEL: 0.5 mg/m³ as TWA

ENVIRONMENT
The substance is harmful to aquatic organisms.

NOTES
There is no odour warning even when toxic concentrations are present. Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.

ADDITIONAL INFORMATION

EC Classification
Symbol: C, T; R: 21-23/25-34-43-48/22; S: (1/2)-25-26-36/37/39-45-46

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