ICSC 1732 - DIMETHYL FUMARATE

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DIMETHYL FUMARATE	ICSC: 1732 (June 2012)
2-Butenedioic acid, dimethylester Boletic acid dimethyl ester Dimethyl (E)-butenedionate trans-1,2-Ethylenedicarboxylic acid dimethyl ester

CAS #: 624-49-7

EC Number: 210-849-0

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Finely dispersed particles form explosive mixtures in air.	NO open flames. Prevent build-up of electrostatic charges (e.g., by grounding).	Use water spray, foam, powder, alcohol-resistant foam. In case of fire: keep drums, etc., cool by spraying with water.

PREVENT DISPERSION OF DUST!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat.	Avoid inhalation of dust.	Fresh air, rest. Seek medical attention if you feel unwell.
Skin	Redness.	Protective gloves.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention if skin irritation occurs.
Eyes	Redness. Pain.	Wear safety goggles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Flushing of the face. Nausea. Vomiting.	Do not eat, drink, or smoke during work.	Rinse mouth.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. If appropriate, moisten first to prevent dusting. Sweep spilled substance into sealable containers. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.	According to UN GHS Criteria Causes serious eye irritation Harmful in contact with skin May be harmful if swallowed May cause an allergic skin reaction Transportation UN Classification
STORAGE
Keep in a well-ventilated room. Well closed. Keep in the dark. Separated from strong oxidants.
PACKAGING
Do not transport with food and feedstuffs.

DIMETHYL FUMARATE

ICSC: 1732

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance WHITE CRYSTALLINE POWDER. Physical dangers If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. Chemical dangers Reacts with strong oxidants. This generates fire and explosion hazard. The substance can form explosive peroxides on prolonged contact with air and light.	Formula: C₆H₈O₄ Molecular mass: 144.13 Boiling point: 193°C Density: 1.37 g/cm³ Melting point: 104°C Vapour pressure: negligible Relative density (water = 1): 1.4 Relative vapour density (air = 1): 5 Solubility in water, g/l: 1.6 (poor) Octanol/water partition coefficient as log Pow: 0.74 (estimated)

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE POWDER.

Physical dangers
If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.

Chemical dangers
Reacts with strong oxidants. This generates fire and explosion hazard. The substance can form explosive peroxides on prolonged contact with air and light.

Formula: C₆H₈O₄
Molecular mass: 144.13
Boiling point: 193°C
Density: 1.37 g/cm³
Melting point: 104°C
Vapour pressure: negligible
Relative density (water = 1): 1.4
Relative vapour density (air = 1): 5
Solubility in water, g/l: 1.6 (poor)
Octanol/water partition coefficient as log Pow: 0.74 (estimated)

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by ingestion and through the skin. Effects of short-term exposure The substance is irritating to the skin and respiratory tract. The substance is severely irritating to the eyes.	Inhalation risk A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. Effects of long-term or repeated exposure Repeated or prolonged contact with skin may cause dermatitis.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion and through the skin.

Effects of short-term exposure
The substance is irritating to the skin and respiratory tract. The substance is severely irritating to the eyes.

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT

NOTES
Products containing more than 0.1% Dimethylfumarate are banned from the market in EU countries.

ADDITIONAL INFORMATION

EC Classification

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