ICSC 1700 - KETOCONAZOLE

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KETOCONAZOLE	ICSC: 1700 (April 2009)
Ketoconazol cis-(+)-1-Acetyl-4-4-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenylpiperazine 1-4-4-(2SR,4RS)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenylpiperazin-1-ylethanone

CAS #: 65277-42-1

UN #: 2811

EC Number: 265-667-4

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Not combustible.		In case of fire in the surroundings, use appropriate extinguishing media.

STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough.	Use local exhaust or breathing protection.	Fresh air, rest.
Skin	Redness.	Protective gloves.	Rinse and then wash skin with water and soap.
Eyes		Wear safety goggles.	Rinse with plenty of water (remove contact lenses if easily possible).
Ingestion	Nausea. Headache. Dizziness. Vomiting. Diarrhoea.	Do not eat, drink, or smoke during work.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria Toxic if swallowed May damage fertility or the unborn child Causes damage to endocrine system through prolonged or repeated exposure if swallowed Very toxic to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Provision to contain effluent from fire extinguishing. Well closed. Separated from food and feedstuffs. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs.

KETOCONAZOLE

ICSC: 1700

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS CRYSTALS OR POWDER. Physical dangers No data. Chemical dangers No data.	Formula: C₂₆H₂₈Cl₂N₄O₄ Molecular mass: 531.5 Melting point: 148-152°C Solubility in water: none Vapour pressure, Pa at 25°C: (negligible) Octanol/water partition coefficient as log Pow: 4.35

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS OR POWDER.

Physical dangers
No data.

Chemical dangers
No data.

Formula: C₂₆H₂₈Cl₂N₄O₄
Molecular mass: 531.5
Melting point: 148-152°C
Solubility in water: none
Vapour pressure, Pa at 25°C: (negligible)
Octanol/water partition coefficient as log Pow: 4.35

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by ingestion. Effects of short-term exposure	Inhalation risk A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure The substance may have effects on the endocrine system and liver. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion.

Effects of short-term exposure

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

Effects of long-term or repeated exposure
The substance may have effects on the endocrine system and liver. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT
The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

NOTES

ADDITIONAL INFORMATION

EC Classification
Symbol: T, N; R: 60-25-48/22-50/53; S: 53-45-60-61; Note: E

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