ICSC 1642 - n-BUTYL ISOCYANATE

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n-BUTYL ISOCYANATE	ICSC: 1642 (April 2007)
1-Isocyanatobutane

CAS #: 111-36-4

UN #: 2485

EC Number: 203-862-8

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Highly flammable. Heating will cause rise in pressure with risk of bursting. Vapour/air mixtures are explosive.	NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting.	Use dry powder, foam, carbon dioxide. NO water. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat. Laboured breathing. Burning sensation.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	Redness. Pain. Skin burns.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes	Redness. Pain. Burns.	Wear safety goggles or eye protection in combination with breathing protection.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Ingestion	Abdominal pain. Burning sensation. Shock or collapse.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Ventilation. Remove all ignition sources. Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Do NOT let this chemical enter the environment.	According to UN GHS Criteria DANGER Highly flammable liquid and vapour Fatal if inhaled Harmful if swallowed Causes severe skin burns and eye damage May cause allergic skin reaction Causes damage to lungs if inhaled Transportation UN Classification UN Hazard Class: 6.1; UN Subsidiary Risks: 3; UN Pack Group: I
STORAGE
Fireproof. Separated from strong oxidants and food and feedstuffs. Cool. See Chemical Dangers. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs.

n-BUTYL ISOCYANATE

ICSC: 1642

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS LIQUID. Physical dangers The vapour mixes well with air, explosive mixtures are easily formed. Chemical dangers The substance may polymerize due to heating. Decomposes on burning. This produces toxic gases including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants and water.	Formula: C₅H₉NO / CH₃(CH₂)₃NCO Molecular mass: 99.1 Boiling point: 115°C Melting point: <-70°C Density: 0.9 g/cm³ Solubility in water: reaction Vapour pressure, kPa at 20°C: 2.1 Relative vapour density (air = 1): 3.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05 Flash point: 11°C c.c. Auto-ignition temperature: 425°C Explosive limits, vol% in air: 1.3-10

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID.

Physical dangers
The vapour mixes well with air, explosive mixtures are easily formed.

Chemical dangers
The substance may polymerize due to heating. Decomposes on burning. This produces toxic gases including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants and water.

Formula: C₅H₉NO / CH₃(CH₂)₃NCO
Molecular mass: 99.1
Boiling point: 115°C
Melting point: <-70°C
Density: 0.9 g/cm³
Solubility in water: reaction
Vapour pressure, kPa at 20°C: 2.1
Relative vapour density (air = 1): 3.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 11°C c.c.
Auto-ignition temperature: 425°C
Explosive limits, vol% in air: 1.3-10

EXPOSURE & HEALTH EFFECTS
Routes of exposure Serious local effects by all routes of exposure. Effects of short-term exposure The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes.	Inhalation risk A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure Repeated or prolonged contact may cause skin sensitization. See Notes.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
Serious local effects by all routes of exposure.

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes.

Inhalation risk
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. See Notes.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms.

NOTES
Some isocyanates are well known to cause respiratory sensitization. However, there are no reports of n-butyl isocyanate or other monoisocyanates causing respiratory sensitization. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.

ADDITIONAL INFORMATION

EC Classification

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