ICSC 1633 - 1-CHLORO-3-NITROBENZENE

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1-CHLORO-3-NITROBENZENE	ICSC: 1633 (April 2007)
Benzene, 1-chloro-3-nitro- m-Chloronitrobenzene

CAS #: 121-73-3

UN #: 1578

EC Number: 204-469-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.	NO open flames.	Use water spray, foam, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Blue lips, fingernails and skin. Dizziness. Headache. Nausea. Confusion. Convulsions.	Use local exhaust. Use breathing protection.	Fresh air, rest. Refer for medical attention. See Notes.
Skin	MAY BE ABSORBED! See Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Redness.	Wear safety goggles.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Ingestion	Blue lips, fingernails and skin. See Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria Harmful if swallowed Toxic in contact with skin Toxic to aquatic life Causes damage to blood Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from combustible substances, reducing agents and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
PACKAGING
Do not transport with food and feedstuffs.

1-CHLORO-3-NITROBENZENE

ICSC: 1633

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance PALE YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR. Physical dangers Dust explosion possible if in powder or granular form, mixed with air. Chemical dangers Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides, chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). This generates fire and explosion hazard. The substance is a strong oxidant. It reacts with combustible and reducing materials.	Formula: ClC₆H₄NO₂ Molecular mass: 157.6 Boiling point: 236°C Melting point: 44°C Density: 1.3 g/cm³ Solubility in water at 20°C: very poor Vapour pressure, Pa at 20°C: 5 Relative vapour density (air = 1): 5.44 Flash point: 103°C c.c. Auto-ignition temperature: 500°C Octanol/water partition coefficient as log Pow: 2.41

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
PALE YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR.

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air.

Chemical dangers
Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides, chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). This generates fire and explosion hazard. The substance is a strong oxidant. It reacts with combustible and reducing materials.

Formula: ClC₆H₄NO₂
Molecular mass: 157.6
Boiling point: 236°C
Melting point: 44°C
Density: 1.3 g/cm³
Solubility in water at 20°C: very poor
Vapour pressure, Pa at 20°C: 5
Relative vapour density (air = 1): 5.44
Flash point: 103°C c.c.
Auto-ignition temperature: 500°C
Octanol/water partition coefficient as log Pow: 2.41

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.	Inhalation risk A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in the formation of methaemoglobin.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in the formation of methaemoglobin.

OCCUPATIONAL EXPOSURE LIMITS
MAK skin absorption (H)

ENVIRONMENT
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

NOTES
TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) BEI issued (ACGIH 2006). See ICSC 0028. Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Rinse contaminated clothing with plenty of water because of fire hazard.

NOTES

TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) BEI issued (ACGIH 2006).
See ICSC 0028.
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Rinse contaminated clothing with plenty of water because of fire hazard.

ADDITIONAL INFORMATION

EC Classification

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