ICSC 1032 - PIPERAZINE (anhydrous)

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PIPERAZINE (anhydrous)	ICSC: 1032 (July 2003)
Antiren 1,4-Diazacyclohexane 1,4-Diethylenediamine Diethyleneimine Hexahydropirazine

CAS #: 110-85-0

UN #: 2579

EC Number: 203-808-3

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 65°C explosive vapour/air mixtures may be formed.	NO open flames. Above 65°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Burning sensation. Cough. Sore throat. Shortness of breath. Laboured breathing. Wheezing.	Avoid inhalation of dust. Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Skin	Skin burns. Pain. Blisters.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer for medical attention .
Eyes	Redness. Pain. Severe burns.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Burning sensation. Abdominal pain. Nausea. Vomiting. Headache. Weakness. Convulsions. Shock or collapse.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 8; UN Pack Group: III
STORAGE
Separated from strong acids, strong oxidants, acid anhydrides, metals and food and feedstuffs. Dry. Well closed.
PACKAGING

PIPERAZINE (anhydrous)

ICSC: 1032

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance HYGROSCOPIC COLOURLESS CRYSTALS OR WHITE FLAKES WITH PUNGENT ODOUR. Physical dangers No data. Chemical dangers Decomposes on burning. This produces toxic and corrosive gases including nitrogen oxides. The solution in water is a medium strong base. Reacts with acid anhydrides, strong acids and strong oxidants. This generates fire hazard. Attacks many metals. This produces flammable/explosive gas (hydrogen - see ICSC 0001).	Formula: C₄H₁₀N₂ Molecular mass: 86.14 Boiling point: 146°C Melting point: 106°C Density: 1.1 g/cm³ Solubility in water, g/100ml at 20°C: 15 Vapour pressure, Pa at 20°C: 21 Relative vapour density (air = 1): 3 Relative density of the vapour/air-mixture at 20°C (air = 1): 1 Flash point: 65°C Auto-ignition temperature: 320°C Explosive limits, vol% in air: 4-14 Octanol/water partition coefficient as log Pow: -1.17

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
HYGROSCOPIC COLOURLESS CRYSTALS OR WHITE FLAKES WITH PUNGENT ODOUR.

Physical dangers
No data.

Chemical dangers
Decomposes on burning. This produces toxic and corrosive gases including nitrogen oxides. The solution in water is a medium strong base. Reacts with acid anhydrides, strong acids and strong oxidants. This generates fire hazard. Attacks many metals. This produces flammable/explosive gas (hydrogen - see ICSC 0001).

Formula: C₄H₁₀N₂
Molecular mass: 86.14
Boiling point: 146°C
Melting point: 106°C
Density: 1.1 g/cm³
Solubility in water, g/100ml at 20°C: 15
Vapour pressure, Pa at 20°C: 21
Relative vapour density (air = 1): 3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1
Flash point: 65°C
Auto-ignition temperature: 320°C
Explosive limits, vol% in air: 4-14
Octanol/water partition coefficient as log Pow: -1.17

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and by ingestion. Effects of short-term exposure The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. See Notes. Ingestion could cause effects on the nervous system. This may result in impaired functions and unconsciousness.	Inhalation risk No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. Effects of long-term or repeated exposure Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. See Notes. Ingestion could cause effects on the nervous system. This may result in impaired functions and unconsciousness.

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.03 ppm as TWA; (SEN); A4 (not classifiable as a human carcinogen). MAK: sensitization of respiratory tract and skin (SAH). EU-OEL: 0.1 mg/m³ as TWA; 0.3 mg/m³ as STEL

ENVIRONMENT
This substance may be hazardous to the environment. Special attention should be given to fish.

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Do NOT take working clothes home.

NOTES

The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: C; R: 34-42/43-52/53; S: (1/2)-22-26-36/37/39-45-61

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