ICSC 0971 - p-ANISIDINE

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p-ANISIDINE	ICSC: 0971 (April 2009)
4-Aminoanisole 4-Methoxybenzenamine 1-Amino-4-methoxybenzene 4-Methoxyaniline

CAS #: 104-94-9

UN #: 2431

EC Number: 203-254-2

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.	NO open flames. Prevent deposition of dust. Closed system, dust explosion-proof electrical equipment and lighting.	Use water spray, foam, powder, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Blue lips, fingernails and skin. Dizziness. Headache.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes	Redness.	Wear face shield or eye protection in combination with breathing protection.	Rinse with plenty of water (remove contact lenses if easily possible).
Ingestion	Nausea. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Harmful if swallowed May be harmful in contact with skin Causes damage to blood Causes damage to the blood through prolonged or repeated exposure Toxic to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Separated from strong oxidants, strong bases, acids, chloroformates and food and feedstuffs. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs.

p-ANISIDINE

ICSC: 0971

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-BROWN CRYSTALS WITH CHARACTERISTIC ODOUR. Physical dangers As a result of flow, agitation, etc., electrostatic charges can be generated. Dust explosion possible if in powder or granular form, mixed with air. Chemical dangers Decomposes on burning. This produces toxic fumes including nitrogen oxides. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. Attacks some coatings, some forms of plastic and rubber.	Formula: C₇H₉NO / H₂NC₆H₄OCH₃ Molecular mass: 123.2 Boiling point: 243°C Melting point: 57°C Density: 1.07 g/cm³ Solubility in water, g/100ml at 20°C: 2.2 (moderate) Vapour pressure, Pa at 20°C: 2 Relative vapour density (air = 1): 4.3 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 122°C Auto-ignition temperature: 515°C Octanol/water partition coefficient as log Pow: 0.95

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-BROWN CRYSTALS WITH CHARACTERISTIC ODOUR.

Physical dangers
As a result of flow, agitation, etc., electrostatic charges can be generated. Dust explosion possible if in powder or granular form, mixed with air.

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. Attacks some coatings, some forms of plastic and rubber.

Formula: C₇H₉NO / H₂NC₆H₄OCH₃
Molecular mass: 123.2
Boiling point: 243°C
Melting point: 57°C
Density: 1.07 g/cm³
Solubility in water, g/100ml at 20°C: 2.2 (moderate)
Vapour pressure, Pa at 20°C: 2
Relative vapour density (air = 1): 4.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 122°C
Auto-ignition temperature: 515°C
Octanol/water partition coefficient as log Pow: 0.95

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Effects of short-term exposure The aerosol is irritating to the eyes and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated. See Notes.	Inhalation risk A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Effects of short-term exposure
The aerosol is irritating to the eyes and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated. See Notes.

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.5 mg/m³, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued. MAK: skin absorption (H); carcinogen category: 3

ENVIRONMENT
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. See ICSC 0970.

ADDITIONAL INFORMATION

EC Classification
Symbol: T+, N; R: 26/27/28-33-50; S: (1/2)-28-36/37-45-61

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