ICSC 0970 - o-ANISIDINE

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o-ANISIDINE	ICSC: 0970 (April 2014)
1-Amino-2-methoxybenzene 2-Methoxyaniline 2-Aminoanisole 2-Methoxybenzenamine

CAS #: 90-04-0

UN #: 2431

EC Number: 201-963-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, foam, powder, carbon dioxide.

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Blue lips, fingernails and skin. Headache. Dizziness.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Administration of oxygen may be needed. Refer immediately for medical attention. See Notes.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	Administration of oxygen may be needed. Remove contaminated clothes. Rinse and then wash skin with water and soap. See Notes. Refer immediately for medical attention.
Eyes	Redness. Pain.	Wear face shield or eye protection in combination with breathing protection.	Rinse with plenty of water (remove contact lenses if easily possible).
Ingestion	Nausea. Further see Inhalation.	Do not eat, drink, or smoke during work.	Administration of oxygen may be needed. Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Harmful if swallowed May be harmful in contact with skin Suspected of causing cancer Causes damage to blood May cause damage to blood through prolonged or repeated exposure Toxic to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Store only in original container. Keep in a well-ventilated room. Separated from strong oxidants, acids, chloroformates and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
PACKAGING
Do not transport with food and feedstuffs.

o-ANISIDINE

ICSC: 0970

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance RED-TO-YELLOW OILY LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. Physical dangers The vapour is heavier than air and may travel along the ground; distant ignition possible. Chemical dangers Decomposes on burning. This produces toxic fumes including nitrogen oxides, carbon monoxide and carbon dioxide. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. This generates fire and explosion hazard. Attacks some coatings, some forms of plastic and rubber.	Formula: C₇H₉NO / NH₂C₆H₄OCH₃ Molecular mass: 123.2 Boiling point: 224-225°C Melting point: 5°C Density (at 20°C): 1.09 g/cm³ Solubility in water, g/100ml at 20°C: 1.5 (moderate) Vapour pressure, kPa at 20°C: 5 Relative vapour density (air = 1): 4.3 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0 Flash point: 107°C c.c. Auto-ignition temperature: 430°C Octanol/water partition coefficient as log Pow: 1.18 Viscosity: 2.028 mm²/s at 55°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
RED-TO-YELLOW OILY LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR.

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible.

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides, carbon monoxide and carbon dioxide. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. This generates fire and explosion hazard. Attacks some coatings, some forms of plastic and rubber.

Formula: C₇H₉NO / NH₂C₆H₄OCH₃
Molecular mass: 123.2
Boiling point: 224-225°C
Melting point: 5°C
Density (at 20°C): 1.09 g/cm³
Solubility in water, g/100ml at 20°C: 1.5 (moderate)
Vapour pressure, kPa at 20°C: 5
Relative vapour density (air = 1): 4.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 107°C c.c.
Auto-ignition temperature: 430°C
Octanol/water partition coefficient as log Pow: 1.18
Viscosity: 2.028 mm²/s at 55°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Effects of short-term exposure The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes. Exposure could cause haemolysis. This may result in haemolytic anaemia. The effects may be delayed. Medical observation is indicated.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia. This substance is possibly carcinogenic to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Effects of short-term exposure
The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes. Exposure could cause haemolysis. This may result in haemolytic anaemia. The effects may be delayed. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia. This substance is possibly carcinogenic to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.5 mg/m³, as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued. MAK: skin absorption (H); carcinogen category: 2

ENVIRONMENT
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. See ICSC 0971.

ADDITIONAL INFORMATION

EC Classification
Symbol: T; R: 45-23/24/25-68; S: 53-45; Note: E

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