ICSC 0846 - 1-CHLORO-4-NITROBENZENE

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1-CHLORO-4-NITROBENZENE	ICSC: 0846 (December 2022)
para-Chloronitrobenzene PCNB PNCB para-Nitrochlorobenzene

CAS #: 100-00-5

UN #: 1578

EC Number: 202-809-6

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.	NO open flames. NO contact with flammables. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.	Use water spray, dry powder, foam, carbon dioxide. Combat fire from a sheltered position.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Blue lips, fingernails and skin. Dizziness. Headache. Nausea. Vomiting. Weakness.	Use local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. See Notes.
Skin	MAY BE ABSORBED! See Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes	Redness.	Wear safety goggles, face shield or eye protection in combination with breathing protection if powder.	Rinse with plenty of water (remove contact lenses if easily possible).
Ingestion	See Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.	According to UN GHS Criteria DANGER Toxic if swallowed, in contact with skin or if inhaled Causes damage to blood Causes damage to blood system and liver through prolonged or repeated exposure Suspected of causing cancer Toxic to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from combustible substances, reducing agents and food and feedstuffs. Ventilation along the floor. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
PACKAGING
Do not transport with food and feedstuffs.

1-CHLORO-4-NITROBENZENE

ICSC: 0846

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance YELLOWISH CRYSTALS WITH CHARACTERISTIC ODOUR. Physical dangers Dust explosion possible if in powder or granular form, mixed with air. Chemical dangers Decomposes on burning. This produces toxic and corrosive fumes of nitrogen oxides, chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). The substance is a strong oxidant. It reacts violently with combustible and reducing materials.	Formula: C₆H₄ClNO₂ Molecular mass: 157.6 Boiling point: 242°C Melting point: 82-84°C Relative density (water = 1): 1.3 Solubility in water: none Vapour pressure, Pa at 30°C: 20 Relative vapour density (air = 1): 5.44 Flash point: 127°C c.c. Octanol/water partition coefficient as log Pow: 2.39 Auto-ignition temperature: 510°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOWISH CRYSTALS WITH CHARACTERISTIC ODOUR.

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air.

Chemical dangers
Decomposes on burning. This produces toxic and corrosive fumes of nitrogen oxides, chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). The substance is a strong oxidant. It reacts violently with combustible and reducing materials.

Formula: C₆H₄ClNO₂
Molecular mass: 157.6
Boiling point: 242°C
Melting point: 82-84°C
Relative density (water = 1): 1.3
Solubility in water: none
Vapour pressure, Pa at 30°C: 20
Relative vapour density (air = 1): 5.44
Flash point: 127°C c.c.
Octanol/water partition coefficient as log Pow: 2.39
Auto-ignition temperature: 510°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.	Inhalation risk A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure The substance may have effects on the blood and liver. This may result in the formation of methaemoglobin, anaemia and liver impairment. This substance is possibly carcinogenic to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

Effects of long-term or repeated exposure
The substance may have effects on the blood and liver. This may result in the formation of methaemoglobin, anaemia and liver impairment. This substance is possibly carcinogenic to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.64 mg/m³, 0.1 ppm, as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued. MAK: skin absorption (H); carcinogen category: 3

ENVIRONMENT
The substance is toxic to aquatic organisms.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment may be necessary in case of poisoning with this substance; the appropriate means with instructions should be available.

ADDITIONAL INFORMATION

EC Classification

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