ICSC 0821 - WARFARIN

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WARFARIN	ICSC: 0821 (November 2010)
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin (RS)-4-hydroxy-3-(3-oxo-1-phenylbutyl)coumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

CAS #: 81-81-2

UN #: 3027

EC Number: 201-377-6

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible.	NO open flames. NO contact with strong oxidizing agents.	Use water spray, foam, powder, carbon dioxide.

AVOID ALL CONTACT! PREVENT DISPERSION OF DUST! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Coughing up blood. Blood in the urine. Bleeding under the skin. Confusion. Symptoms may be delayed. See Notes.	Use closed system.	Refer for medical attention.
Skin	EASILY ABSORBED! See Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. See Notes. Rinse and then wash skin with water and soap. Refer immediately for medical attention .
Eyes		Wear face shield or eye protection in combination with breathing protection if powder.	Rinse with plenty of water (remove contact lenses if easily possible).
Ingestion	Diarrhoea. Nausea. Vomiting. Abdominal pain. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Fatal if swallowed or if inhaled Harmful in contact with skin May damage fertility or the unborn child Causes damage to blood system Causes damage to blood system through prolonged or repeated exposure Harmful to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: I
STORAGE
Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access.
PACKAGING
Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. Marine pollutant.

WARFARIN

ICSC: 0821

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-WHITE POWDER. Physical dangers Chemical dangers Reacts with strong oxidants. This generates fire and explosion hazard. Decomposes on heating. This produces irritating fumes.	Formula: C₁₉H₁₆O₄ Molecular mass: 308.3 Decomposes Melting point: 161°C Relative density (water = 1): 1.4 Solubility in water, g/100ml at 20°C: 0.0017 (very poor) Vapour pressure, Pa at 20°C: (negligible) Relative vapour density (air = 1): 10.6 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Octanol/water partition coefficient as log Pow: 2.6

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-WHITE POWDER.

Physical dangers

Chemical dangers
Reacts with strong oxidants. This generates fire and explosion hazard. Decomposes on heating. This produces irritating fumes.

Formula: C₁₉H₁₆O₄
Molecular mass: 308.3
Decomposes
Melting point: 161°C
Relative density (water = 1): 1.4
Solubility in water, g/100ml at 20°C: 0.0017 (very poor)
Vapour pressure, Pa at 20°C: (negligible)
Relative vapour density (air = 1): 10.6
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Octanol/water partition coefficient as log Pow: 2.6

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Effects of short-term exposure The substance may cause effects on the blood. This may result in bleeding. The effects may be delayed. Medical observation is indicated. See Notes. Exposure could cause death.	Inhalation risk A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in bleeding. Causes toxicity to human reproduction or development.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Effects of short-term exposure
The substance may cause effects on the blood. This may result in bleeding. The effects may be delayed. Medical observation is indicated. See Notes. Exposure could cause death.

Inhalation risk
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in bleeding. Causes toxicity to human reproduction or development.

OCCUPATIONAL EXPOSURE LIMITS
TLV: (inhalable fraction): 0.01 mg/m³, as TWA; (skin). MAK: 0.02 mg/m³, 0.0016 ppm; peak limitation category: II(8); skin absorption (H); pregnancy risk group: B

ENVIRONMENT
The substance is harmful to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to mammals. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

NOTES
Warfarin is usually available commercially as the water soluble sodium salt (CAS 129-06-6). The physical properties above refer to the parent substance. The symptoms of bleeding do not become manifest after one or two days. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Do NOT take working clothes home. This CAS number is for the racemic mixture; other CAS numbers: 5543-57-7 (S-warfarin), 5543-58-8 (R-warfarin)

NOTES

Warfarin is usually available commercially as the water soluble sodium salt (CAS 129-06-6). The physical properties above refer to the parent substance.
The symptoms of bleeding do not become manifest after one or two days.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Do NOT take working clothes home.
This CAS number is for the racemic mixture; other CAS numbers: 5543-57-7 (S-warfarin), 5543-58-8 (R-warfarin)

ADDITIONAL INFORMATION

EC Classification
Symbol: T; R: 61-48/25-52/53; S: 53-45-61; Note: E

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