ICSC 0753

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EPN	ICSC: 0753 (November 2008)
Phosphonothioic acid, phenyl-, O-ethyl O-(4-nitrophenyl) ester O-Ethyl O-4-nitrophenyl phenyl phosphonothioate

CAS #: 2104-64-5

UN #: 2783

EC Number: 218-276-8

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use powder, alcohol-resistant foam, water spray, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Dizziness. Pupillary constriction. Muscle cramps. Excessive salivation. Sweating. Muscle twitching. Nausea.	Use local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	MAY BE ABSORBED! Redness. Pain. Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. Wear protective gloves when administering first aid. Put clothes in sealable container. See Notes.
Eyes	Redness. Blurred vision.	Wear face shield or eye protection in combination with breathing protection if powder. Wear safety spectacles.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
Ingestion	Nausea. Abdominal cramps. Vomiting. Diarrhoea. Drowsiness. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.	According to UN GHS Criteria DANGER Fatal if swallowed, in contact with skin or if inhaled Causes damage to nervous system if nervous system Very toxic to aquatic life with long lasting effects Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: I
STORAGE
Separated from strong oxidizers and food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs. Severe marine pollutant.

EPN

ICSC: 0753

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance YELLOW CRYSTALLINE POWDER WITH CHARACTERISTIC ODOUR. Physical dangers Chemical dangers Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides, phosphorus oxides and sulfur oxides. Reacts with strong oxidants. This generates fire and explosion hazard. Decomposes under the influence of bases. This produces p-nitrophenol (see ICSC 0066).	Formula: C₁₄H₁₄NO₄PS Molecular mass: 323.3 Boiling point at 0.667kPa: 215°C Melting point: 36°C Density: 1.3 g/cm³ Solubility in water: none Vapour pressure, Pa at 25°C: <0.01 Octanol/water partition coefficient as log Pow: 4.78

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW CRYSTALLINE POWDER WITH CHARACTERISTIC ODOUR.

Physical dangers

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides, phosphorus oxides and sulfur oxides. Reacts with strong oxidants. This generates fire and explosion hazard. Decomposes under the influence of bases. This produces p-nitrophenol (see ICSC 0066).

Formula: C₁₄H₁₄NO₄PS
Molecular mass: 323.3
Boiling point at 0.667kPa: 215°C
Melting point: 36°C
Density: 1.3 g/cm³
Solubility in water: none
Vapour pressure, Pa at 25°C: <0.01
Octanol/water partition coefficient as log Pow: 4.78

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes and skin. Cholinesterase inhibition. The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Exposure could cause unconsciousness and death. The effects may be delayed. Medical observation is indicated.	Inhalation risk A harmful concentration of airborne particles can be reached quickly. Effects of long-term or repeated exposure Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes and skin. Cholinesterase inhibition. The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Exposure could cause unconsciousness and death. The effects may be delayed. Medical observation is indicated.

Inhalation risk
A harmful concentration of airborne particles can be reached quickly.

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

OCCUPATIONAL EXPOSURE LIMITS
TLV: (inhalable fraction and vapour): 0.1 mg/m³, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued. MAK: (inhalable fraction): 0.5 mg/m³; peak limitation category: II(2); skin absorption (H)

ENVIRONMENT
The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Isolate contaminated clothing by sealing in a bag or other container. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home.

NOTES

Depending on the degree of exposure, periodic medical examination is suggested.
Isolate contaminated clothing by sealing in a bag or other container.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: T+, N; R: 27/28-50/53; S: (1/2)-22-36/37-45-60-61

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