ICSC 0558 - PROPIONIC ANHYDRIDE

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PROPIONIC ANHYDRIDE	ICSC: 0558 (October 2005)
Propanoic anhydride Methylacetic anhydride Propanoic acid anhydride

CAS #: 123-62-6

UN #: 2496

EC Number: 204-638-2

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Above 63°C explosive vapour/air mixtures may be formed.	NO open flames. Above 63°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide.

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sore throat. Cough. Burning sensation. Shortness of breath. Symptoms may be delayed. See Notes.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	Pain. Skin burns.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes	Redness. Pain. Severe burns.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Burning sensation. Sore throat. Abdominal pain. Shock or collapse.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit and face shield. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 8; UN Pack Group: III
STORAGE
Dry. Ventilation along the floor. Separated from bases, oxidants and food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

PROPIONIC ANHYDRIDE

ICSC: 0558

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS LIQUID WITH PUNGENT ODOUR. Physical dangers The vapour is heavier than air. Chemical dangers Decomposes on contact with water. This produces corrosive propionic acid. Reacts violently with bases and oxidants. This generates fire and explosion hazard.	Formula: C₆H₁₀O₃ / (CH₃CH₂CO)₂O Molecular mass: 130.2 Boiling point: 167°C Melting point: -45°C Relative density (water = 1): 1.01 Solubility in water: reaction Vapour pressure, kPa at 20°C: 0.1 Relative vapour density (air = 1): 4.5 Relative density of the vapour/air-mixture at 20°C (air = 1): 4.4 Flash point: 63°C c.c. Auto-ignition temperature: 285°C Explosive limits, vol% in air: 1.3-9.5

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH PUNGENT ODOUR.

Physical dangers
The vapour is heavier than air.

Chemical dangers
Decomposes on contact with water. This produces corrosive propionic acid. Reacts violently with bases and oxidants. This generates fire and explosion hazard.

Formula: C₆H₁₀O₃ / (CH₃CH₂CO)₂O
Molecular mass: 130.2
Boiling point: 167°C
Melting point: -45°C
Relative density (water = 1): 1.01
Solubility in water: reaction
Vapour pressure, kPa at 20°C: 0.1
Relative vapour density (air = 1): 4.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 4.4
Flash point: 63°C c.c.
Auto-ignition temperature: 285°C
Explosive limits, vol% in air: 1.3-9.5

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and by ingestion. Effects of short-term exposure The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour or aerosol may cause lung oedema. See Notes. Corrosive on ingestion. The effects may be delayed. Medical observation is indicated.	Inhalation risk No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. Effects of long-term or repeated exposure

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour or aerosol may cause lung oedema. See Notes. Corrosive on ingestion. The effects may be delayed. Medical observation is indicated.

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.

Effects of long-term or repeated exposure

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered.

ADDITIONAL INFORMATION

EC Classification
Symbol: C; R: 34; S: (1/2)-26-45

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