ICSC 0555 - beta-PROPIOLACTONE

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beta-PROPIOLACTONE	ICSC: 0555 (April 2017)
1,3-Propiolactone 2-Oxetanone Propanolide

CAS #: 57-57-8

UN #: 2810

EC Number: 200-340-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Above 74°C explosive vapour/air mixtures may be formed.	NO open flames. Above 74°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

AVOID ALL CONTACT!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Burning sensation. Cough. Sore throat. Headache. Nausea. Shortness of breath. Vomiting.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	Redness.	Protective gloves. Protective clothing.	Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes	Redness. Pain. Burns.	Wear safety goggles or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	See Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: self-contained breathing apparatus. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Combustible liquid Fatal if inhaled Causes skin irritation Causes serious eye irritation May cause cancer May cause respiratory irritation Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: I
STORAGE
Separated from food and feedstuffs. Cooled. Well closed. Ventilation along the floor.
PACKAGING
Do not transport with food and feedstuffs.

beta-PROPIOLACTONE

ICSC: 0555

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS LIQUID WITH PUNGENT ODOUR. Physical dangers Chemical dangers The substance may polymerize due to warming. This generates fire or explosion hazard.	Formula: C₃H₄O₂ Molecular mass: 72.1 Decomposes at 162°C Melting point: -33.4°C Density (at 20°C): 1.1 g/ml Solubility in water, g/100ml at 25°C: 37 (good) Vapour pressure, Pa at 25°C: 453 Flash point: 74°C c.c. Explosive limits, vol% in air: 2.9-? Octanol/water partition coefficient as log Pow: 0.46 (estimated) Relative vapour density (air = 1): 2.5 (calculated) Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH PUNGENT ODOUR.

Physical dangers

Chemical dangers
The substance may polymerize due to warming. This generates fire or explosion hazard.

Formula: C₃H₄O₂
Molecular mass: 72.1
Decomposes at 162°C
Melting point: -33.4°C
Density (at 20°C): 1.1 g/ml
Solubility in water, g/100ml at 25°C: 37 (good)
Vapour pressure, Pa at 25°C: 453
Flash point: 74°C c.c.
Explosive limits, vol% in air: 2.9-?
Octanol/water partition coefficient as log Pow: 0.46 (estimated)
Relative vapour density (air = 1): 2.5 (calculated)
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and by ingestion. Effects of short-term exposure The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying. Effects of long-term or repeated exposure This substance is probably carcinogenic to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Effects of short-term exposure
The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying.

Effects of long-term or repeated exposure
This substance is probably carcinogenic to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.5 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans). MAK: skin absorption (H); carcinogen category: 2

ENVIRONMENT
Environmental effects from the substance have not been investigated adequately.

NOTES

ADDITIONAL INFORMATION

EC Classification
Symbol: T+; R: 45-26-36/38; S: 53-45; Note: E

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