ICSC 0520 - NICOTINE SULFATE

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NICOTINE SULFATE	ICSC: 0520 (November 2023)
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine;sulfuric acid (-)-1-Methyl-2-(3-pyridyl)-pyrrolidine sulfate (S)-3-(1-Methyl-2-pyrrolidinyl)-pyridine sulfate 3-(1-Methyl-2-pyrrolidinyl)-pyridine sulfate

CAS #: 65-30-5

UN #: 1658

EC Number: 200-606-7

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, powder, alcohol-resistant foam, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough.	Use local exhaust, ventilation and breathing protection.	Fresh air, rest. Refer for medical attention.
Skin		Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes	Redness.	Wear face shield or eye protection in combination with breathing protection if powder.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Burning sensation. Confusion. Nausea. Vomiting. Excessive salivation. Diarrhoea. Sweating. Dizziness. Convulsions. Drowsiness. Respiratory arrest.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give a slurry of activated charcoal in water to drink, but NOT if convulsions occur. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: complete protective clothing and particulate filter respirator adapted to the airborne concentration of the substance. Do NOT wash away into sewer. If appropriate, moisten first to prevent dusting. Sweep spilled substance into covered containers. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Fatal if swallowed May cause damage to central nervous system and cardiovascular system Toxic to aquatic life with long lasting effects Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
PACKAGING
Do not transport with food and feedstuffs. Put breakable packaging into closed unbreakable container.

NICOTINE SULFATE

ICSC: 0520

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS CRYSTALS. Physical dangers Chemical dangers Decomposes on heating. This produces toxic fumes of sulfur oxides and nitrogen oxides. Reacts violently with strong oxidants. This generates explosion hazard.	Formula: C₂₀H₂₆N₄.O₄S Molecular mass: 418.6 Relative density (water = 1): 1.15 Solubility in water: soluble

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS.

Physical dangers

Chemical dangers
Decomposes on heating. This produces toxic fumes of sulfur oxides and nitrogen oxides. Reacts violently with strong oxidants. This generates explosion hazard.

Formula: C₂₀H₂₆N₄.O₄S
Molecular mass: 418.6
Relative density (water = 1): 1.15
Solubility in water: soluble

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. Effects of short-term exposure The substance is irritating to the eyes and skin. The substance may cause effects on the central nervous system and cardiovascular system. This may result in central nervous system depression and respiratory depression. The effects may be delayed. Medical observation is indicated.	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. Effects of long-term or repeated exposure Animal tests show that this substance possibly causes toxic effects upon human reproduction.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes and skin. The substance may cause effects on the central nervous system and cardiovascular system. This may result in central nervous system depression and respiratory depression. The effects may be delayed. Medical observation is indicated.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.

Effects of long-term or repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction.

OCCUPATIONAL EXPOSURE LIMITS
TLV (see Notes). EUL (see Notes)

ENVIRONMENT
The substance is toxic to aquatic organisms.

NOTES
See ICSC 0519.

ADDITIONAL INFORMATION

EC Classification

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