ICSC 0519 - NICOTINE

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NICOTINE	ICSC: 0519 (November 2023)
3-(N-Methyl-2-pyrrolidinyl)pyridine 3-(Tetrahydro-1-methylpyrrol-2-yl) 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine (S)-3-(1-Methylpyrrolidin-2-yl)pyridine 3-(1-Methyl-2-pyrrolidinyl)pyridine beta-Pyridyl-alpha-N-methylpyrrolidine 1-Methyl-2-(3-pyridyl)pyrrolidine

CAS #: 54-11-5

UN #: 1654

EC Number: 200-193-3

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire. Above 111°C explosive vapour/air mixtures may be formed.	NO open flames. Above 111°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide.

PREVENT GENERATION OF MISTS! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Burning sensation. Confusion. Nausea. Vomiting. Excessive salivation. Diarrhoea. Sweating. Dizziness. Convulsions. Lethargy. Respiratory and cardiac arrest.	Use local exhaust, ventilation and breathing protection.	Fresh air, rest. Refer immediately for medical attention.
Skin	MAY BE ABSORBED! Redness. See Inhalation.	Protective gloves. Protective clothing.	Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.
Eyes	Redness. Pain.	Wear safety goggles, face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	See Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give a slurry of activated charcoal in water to drink, but NOT if convulsions occur. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria Fatal if swallowed, in contact with skin or if inhaled May cause damage to central nervous system and cardiovascular system Toxic to aquatic life with long lasting effects Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Dry. Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
PACKAGING
Do not transport with food and feedstuffs. Put breakable packaging into closed unbreakable container.

NICOTINE

ICSC: 0519

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance OILY COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. Physical dangers Chemical dangers Decomposes on heating. This produces toxic fumes including nitrogen oxides and carbon monoxide. Reacts violently with strong oxidants. This generates explosion hazard.	Formula: C₁₀H₁₄N₂ Molecular mass: 162.2 Decomposes at 247°C Melting point: -79°C Relative density (water = 1): 1.01 Solubility in water: miscible Vapour pressure, kPa at 20°C: 0.006 Relative vapour density (air = 1): 5.6 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 111°C Auto-ignition temperature: 240°C Explosive limits, vol% in air: 0.7-4 Octanol/water partition coefficient as log Pow: 0.28 (pH-dependent) Boiling point: 249°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
OILY COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR.

Physical dangers

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides and carbon monoxide. Reacts violently with strong oxidants. This generates explosion hazard.

Formula: C₁₀H₁₄N₂
Molecular mass: 162.2
Decomposes at 247°C
Melting point: -79°C
Relative density (water = 1): 1.01
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 0.006
Relative vapour density (air = 1): 5.6
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 111°C
Auto-ignition temperature: 240°C
Explosive limits, vol% in air: 0.7-4
Octanol/water partition coefficient as log Pow: 0.28 (pH-dependent)
Boiling point: 249°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes and skin. The substance may cause effects on the cardiovascular system and central nervous system. This may result in respiratory depression and central nervous system depression. The effects may be delayed. Medical observation is indicated.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure Animal tests show that this substance possibly causes toxic effects upon human reproduction.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes and skin. The substance may cause effects on the cardiovascular system and central nervous system. This may result in respiratory depression and central nervous system depression. The effects may be delayed. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.5 mg/m³, as TWA; (skin). EU-OEL: 0.5 mg/m³ as TWA; (skin)

ENVIRONMENT
The substance is toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. Avoid release to the environment in circumstances different to normal use.

NOTES

ADDITIONAL INFORMATION

EC Classification
GHS09; GHS06. DANGER. H300; H310; H330; H411.

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