ICSC 0405 - CAFFEINE

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CAFFEINE	ICSC: 0405 (March 1998)
1,3,7-Trimethylxanthine 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione Methyltheobromine Methyltheophylline

CAS #: 58-08-2

UN #: 1544

EC Number: 200-362-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, dry powder.

PREVENT DISPERSION OF DUST!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	See Ingestion.	Use local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin		Protective gloves.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes	Redness.	Wear safety spectacles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Headache. Dizziness. Abdominal cramps. Nausea. Vomiting. Convulsions. Tremor.	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 6.1
STORAGE
Separated from food and feedstuffs. Well closed.
PACKAGING
Do not transport with food and feedstuffs.

CAFFEINE

ICSC: 0405

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance ODOURLESS WHITE CRYSTALS OR CRYSTALLINE POWDER. Physical dangers Chemical dangers Decomposes on burning. This produces toxic fumes including nitrogen oxides.	Formula: C₈H₁₀N₄O₂ Molecular mass: 194.19 Melting point: 235°C Boiling point: 178°C (sublimes) Density: 1.23 g/cm³ Solubility in water, g/100ml: 2.17 Octanol/water partition coefficient as log Pow: -0.07

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
ODOURLESS WHITE CRYSTALS OR CRYSTALLINE POWDER.

Physical dangers

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides.

Formula: C₈H₁₀N₄O₂
Molecular mass: 194.19
Melting point: 235°C
Boiling point: 178°C (sublimes)
Density: 1.23 g/cm³
Solubility in water, g/100ml: 2.17
Octanol/water partition coefficient as log Pow: -0.07

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and by ingestion. Effects of short-term exposure The substance may cause effects on the central nervous system and cardiovascular system. This may result in insomnia, excitement, tachycardia and polyuria.	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. Effects of long-term or repeated exposure

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Effects of short-term exposure
The substance may cause effects on the central nervous system and cardiovascular system. This may result in insomnia, excitement, tachycardia and polyuria.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

Effects of long-term or repeated exposure

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT
Environmental effects from the substance have not been investigated adequately.

NOTES

ADDITIONAL INFORMATION

EC Classification
Symbol: Xn; R: 22; S: (2)

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