ICSC 0376 - ANTIPYRINE

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ANTIPYRINE	ICSC: 0376 (April 2013)
2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one Phenazone 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one

CAS #: 60-80-0

EC Number: 200-486-6

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, powder, foam, carbon dioxide.

PREVENT DISPERSION OF DUST!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest.
Skin	No acute symptoms expected.	Protective gloves.	Rinse skin with plenty of water or shower.
Eyes	Redness.	Wear safety spectacles.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Ingestion	No acute symptoms expected.	Do not eat, drink, or smoke during work.	Rinse mouth. Seek medical attention if you feel unwell.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria WARNING Harmful if swallowed Transportation UN Classification
STORAGE
Separated from strong oxidants.
PACKAGING

ANTIPYRINE

ICSC: 0376

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS CRYSTALS OR WHITE POWDER. Physical dangers Dust explosion possible if in powder or granular form, mixed with air. Chemical dangers Decomposes on heating. This produces toxic and corrosive fumes of nitrogen oxides. Reacts with strong oxidants.	Formula: C₁₁H₁₂N₂O Molecular mass: 188.2 Boiling point: 319°C Melting point: 113°C Relative density (water = 1): 1.19 Solubility in water: very good Octanol/water partition coefficient as log Pow: 0,23

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS OR WHITE POWDER.

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air.

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes of nitrogen oxides. Reacts with strong oxidants.

Formula: C₁₁H₁₂N₂O
Molecular mass: 188.2
Boiling point: 319°C
Melting point: 113°C
Relative density (water = 1): 1.19
Solubility in water: very good
Octanol/water partition coefficient as log Pow: 0,23

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of dust and by ingestion. Effects of short-term exposure May cause mechanical irritation to the eyes and respiratory tract.	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in anaemia.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of dust and by ingestion.

Effects of short-term exposure
May cause mechanical irritation to the eyes and respiratory tract.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in anaemia.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT

NOTES
Health effects of exposure to the substance have not been investigated adequately.

ADDITIONAL INFORMATION

EC Classification

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