ICSC 0308 - 4-NITROANILINE

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4-NITROANILINE	ICSC: 0308 (December 2001)
p-Nitroaniline 1-Amino-4-nitrobenzene C.I. 37035

CAS #: 100-01-6

UN #: 1661

EC Number: 202-810-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Many reactions may cause fire or explosion. Finely dispersed particles form explosive mixtures in air.	NO open flames. NO contact with combustible substances. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.	Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

PREVENT DISPERSION OF DUST!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Blue lips, fingernails and skin. Headache. Dizziness. Nausea. Confusion. Convulsions. Laboured breathing. Unconsciousness.	Use local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes	Redness. Pain.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from strong acids, strong oxidants, combustible substances, reducing agents and food and feedstuffs. Dry.
PACKAGING
Do not transport with food and feedstuffs.

4-NITROANILINE

ICSC: 0308

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance YELLOW CRYSTALS OR POWDER. Physical dangers Dust explosion possible if in powder or granular form, mixed with air. Chemical dangers May explode on heating. On combustion, forms toxic fumes of nitrogen oxides. Reacts with strong acids, strong oxidants and strong reducing agents. Reacts with organic materials in the presence of moisture. This generates fire hazard.	Formula: C₆H₆N₂O₂ Molecular mass: 138.1 Boiling point: 332°C Melting point: 148°C Density: 1.4 g/cm³ Solubility in water, g/100ml at 18.5°C: 0.08 Vapour pressure, Pa at 20°C: 0.2 Relative vapour density (air = 1): 4.8 Flash point: 199°C Octanol/water partition coefficient as log Pow: 2.66

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW CRYSTALS OR POWDER.

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air.

Chemical dangers
May explode on heating. On combustion, forms toxic fumes of nitrogen oxides. Reacts with strong acids, strong oxidants and strong reducing agents. Reacts with organic materials in the presence of moisture. This generates fire hazard.

Formula: C₆H₆N₂O₂
Molecular mass: 138.1
Boiling point: 332°C
Melting point: 148°C
Density: 1.4 g/cm³
Solubility in water, g/100ml at 18.5°C: 0.08
Vapour pressure, Pa at 20°C: 0.2
Relative vapour density (air = 1): 4.8
Flash point: 199°C
Octanol/water partition coefficient as log Pow: 2.66

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Effects of short-term exposure The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C , on spraying or dispersing much faster. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in the formation of methaemoglobin. See Notes.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Effects of short-term exposure
The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C , on spraying or dispersing much faster.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in the formation of methaemoglobin. See Notes.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 3 mg/m³, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued. MAK: skin absorption (H); carcinogen category: 3

ENVIRONMENT
The substance is harmful to aquatic organisms.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. See ICSCs 0306 and 0307.

ADDITIONAL INFORMATION

EC Classification
Symbol: T; R: 23/24/25-33-52/53; S: (1/2)-28-36/37-45-61; Note: C

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