ICSC 0278 - HEXAMETHYLENE DIISOCYANATE

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HEXAMETHYLENE DIISOCYANATE	ICSC: 0278 (April 2017)
HMDI 1,6-Hexamethylene diisocyanate 1,6-Diisocyanatohexane

CAS #: 822-06-0

UN #: 2281

EC Number: 212-485-8

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use powder, carbon dioxide.

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! FIRST AID: USE PERSONAL PROTECTION.
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Burning sensation. Cough. Sore throat. Laboured breathing. Shortness of breath.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	MAY BE ABSORBED! Redness.	Protective gloves.	Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes	Redness. Pain. Swelling of the eyelids.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion		Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Fatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from incompatible materials and food and feedstuffs. See Chemical Dangers. Cool. Dry. Keep in the dark. Ventilation along the floor.
PACKAGING
Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.

HEXAMETHYLENE DIISOCYANATE

ICSC: 0278

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance CLEAR COLOURLESS LIQUID WITH PUNGENT ODOUR. Physical dangers Chemical dangers The substance polymerizes under the influence of temperatures above 93°C. On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492). Decomposes on contact with water. This produces amine and polyureas. Reacts violently with acids, alcohols, amines, bases and oxidants. This generates fire and explosion hazard. Attacks copper.	Formula: C₈H₁₂N₂O₂ / OCN-(CH₂)₆-NCO Molecular mass: 168.2 Boiling point: 255°C Melting point: -67°C Relative density (water = 1): 1.05 Solubility in water: reaction Vapour pressure, Pa at 25°C: 7 Relative vapour density (air = 1): 5.8 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 140°C o.c. Auto-ignition temperature: 454°C Explosive limits, vol% in air: 0.9-9.5 Octanol/water partition coefficient as log Pow: 1.08

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
CLEAR COLOURLESS LIQUID WITH PUNGENT ODOUR.

Physical dangers

Chemical dangers
The substance polymerizes under the influence of temperatures above 93°C. On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492). Decomposes on contact with water. This produces amine and polyureas. Reacts violently with acids, alcohols, amines, bases and oxidants. This generates fire and explosion hazard. Attacks copper.

Formula: C₈H₁₂N₂O₂ / OCN-(CH₂)₆-NCO
Molecular mass: 168.2
Boiling point: 255°C
Melting point: -67°C
Relative density (water = 1): 1.05
Solubility in water: reaction
Vapour pressure, Pa at 25°C: 7
Relative vapour density (air = 1): 5.8
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 140°C o.c.
Auto-ignition temperature: 454°C
Explosive limits, vol% in air: 0.9-9.5
Octanol/water partition coefficient as log Pow: 1.08

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol or vapour and through the skin. Effects of short-term exposure The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation may cause asthmatic reactions.	Inhalation risk A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. Effects of long-term or repeated exposure Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol or vapour and through the skin.

Effects of short-term exposure
The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation may cause asthmatic reactions.

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.005 ppm as TWA. MAK: 0.035 mg/m³, 0.005 ppm; peak limitation category: I(1); sensitization of respiratory tract and skin (SAH); pregnancy risk group: D

ENVIRONMENT

NOTES
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact. Anyone who has shown skin sensitization due to this substance should avoid all further contact. Workers exposed to this compound may also be sensitized to other isocyanates. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home.

NOTES

The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
Anyone who has shown skin sensitization due to this substance should avoid all further contact.
Workers exposed to this compound may also be sensitized to other isocyanates.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home.

ADDITIONAL INFORMATION

Seveso substances: Yes, categories H2 EC Classification
Symbol: T; R: 23-36/37/38-42/43; S: (1/2)-26-28-38-45

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