ICSC 0192 - PROPYLENE OXIDE

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PROPYLENE OXIDE	ICSC: 0192 (November 2009)
Methyl ethylene oxide Propene oxide 1,2-Epoxypropane Methyloxirane

CAS #: 75-56-9

UN #: 1280

EC Number: 200-879-2

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Extremely flammable. Heating will cause rise in pressure with risk of bursting. Vapour/air mixtures are explosive.	NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.	Use alcohol-resistant foam, foam, water spray. In case of fire: keep drums, etc., cool by spraying with water.

STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Seek medical attention if you feel unwell.
Skin	Redness.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes	Redness. Pain.	Wear safety goggles or eye protection in combination with breathing protection.	Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
Ingestion	Sore throat.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Refer for medical attention if breathing difficulties and/or fever develop.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Extremely flammable liquid and vapour Harmful if swallowed, in contact with skin or if inhaled Causes skin and eye irritation Suspected of causing genetic defects Suspected of causing cancer May cause respiratory irritation May be harmful if swallowed and enters airways Transportation UN Classification UN Hazard Class: 3; UN Pack Group: I
STORAGE
Fireproof. Separated from acids, bases and strong oxidants. Dry. Cool. Well closed. Keep in the dark.
PACKAGING
Unbreakable packaging. Put breakable packaging into closed unbreakable container.

PROPYLENE OXIDE

ICSC: 0192

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance VERY VOLATILE COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Physical dangers The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated. Chemical dangers The substance may violently polymerize under the influence of bases, acids and metal chlorides. This generates fire and explosion hazard. Reacts violently with chlorine, ammonia, strong oxidants and acids. This generates fire or explosion hazard.	Formula: C₃H₆O / CH₃CHCH₂O Molecular mass: 58.1 Boiling point: 34°C Melting point: -112°C Relative density (water = 1): 0.83 Solubility in water, g/100ml at 20°C: 40 Vapour pressure, kPa at 20°C: 59 Relative vapour density (air = 1): 2.0 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.6 Flash point: -37°C c.c. Auto-ignition temperature: 430°C Explosive limits, vol% in air: 1.9-36.3 Octanol/water partition coefficient as log Pow: 0.03 Viscosity: 0.34 mm²/s at 25°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
VERY VOLATILE COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.

Chemical dangers
The substance may violently polymerize under the influence of bases, acids and metal chlorides. This generates fire and explosion hazard. Reacts violently with chlorine, ammonia, strong oxidants and acids. This generates fire or explosion hazard.

Formula: C₃H₆O / CH₃CHCH₂O
Molecular mass: 58.1
Boiling point: 34°C
Melting point: -112°C
Relative density (water = 1): 0.83
Solubility in water, g/100ml at 20°C: 40
Vapour pressure, kPa at 20°C: 59
Relative vapour density (air = 1): 2.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.6
Flash point: -37°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 1.9-36.3
Octanol/water partition coefficient as log Pow: 0.03
Viscosity: 0.34 mm²/s at 25°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.	Inhalation risk A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure Repeated or prolonged contact with skin may cause dermatitis. This substance is possibly carcinogenic to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. This substance is possibly carcinogenic to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 2 ppm as TWA; (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans). EU-OEL: 2.4 mg/m³, 1 ppm as TWA. MAK: 4.8 mg/m³, 2 ppm; peak limitation category: I(2); sensitization of skin (SH); carcinogen category: 4; pregnancy risk group: C

ENVIRONMENT

NOTES
Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: F+, T; R: 45-46-12-20/21/22-36/37/38; S: 53-45; Note: E

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