ICSC 0162 - HEXAMETHYLPHOSPHORIC TRIAMIDE

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HEXAMETHYLPHOSPHORIC TRIAMIDE	ICSC: 0162 (April 2017)
Hexamethylphosphoramide Hexamethylphosphamide HMPA

CAS #: 680-31-9

EC Number: 211-653-8

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, powder, alcohol-resistant foam, carbon dioxide.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation		Use ventilation, local exhaust or breathing protection.	Refer for medical attention.
Skin	MAY BE ABSORBED!	Protective gloves. Protective clothing.	Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes		Wear safety spectacles or face shield.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion		Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Suspected of causing cancer May cause genetic defects Transportation UN Classification
STORAGE
Ventilation along the floor. Separated from acids and oxidants.
PACKAGING

HEXAMETHYLPHOSPHORIC TRIAMIDE

ICSC: 0162

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS MOBILE LIQUID. Physical dangers Chemical dangers Decomposes on heating and on burning. Reacts with acids and oxidants. This produces toxic fumes including phosphorus oxides and nitrogen oxides.	Formula: C₆H₁₈N₃OP / {(CH₃)₂N}₃P(O) Molecular mass: 179.2 Boiling point: 232°C Melting point: 7.2°C Relative density (water = 1): 1.03 Solubility in water: very good Vapour pressure, Pa at 20°C: 4 Relative vapour density (air = 1): 6.18 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 105°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS MOBILE LIQUID.

Physical dangers

Chemical dangers
Decomposes on heating and on burning. Reacts with acids and oxidants. This produces toxic fumes including phosphorus oxides and nitrogen oxides.

Formula: C₆H₁₈N₃OP / {(CH₃)₂N}₃P(O)
Molecular mass: 179.2
Boiling point: 232°C
Melting point: 7.2°C
Relative density (water = 1): 1.03
Solubility in water: very good
Vapour pressure, Pa at 20°C: 4
Relative vapour density (air = 1): 6.18
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 105°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and through the skin. Effects of short-term exposure Exposure to high concentrations could cause effects on the nervous system, kidneys and respiratory tract.	Inhalation risk No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. Effects of long-term or repeated exposure The substance may have effects on the respiratory tract, kidneys and testes. This substance is possibly carcinogenic to humans. May cause genetic damage in humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin.

Effects of short-term exposure
Exposure to high concentrations could cause effects on the nervous system, kidneys and respiratory tract.

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.

Effects of long-term or repeated exposure
The substance may have effects on the respiratory tract, kidneys and testes. This substance is possibly carcinogenic to humans. May cause genetic damage in humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: (skin); A3 (confirmed animal carcinogen with unknown relevance to humans). MAK: skin absorption (H); carcinogen category: 2; germ cell mutagen group: 2

ENVIRONMENT

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. See ICSC 0695.

ADDITIONAL INFORMATION

EC Classification
Symbol: T; R: 45-46; S: 53-45

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