ICSC 0159 - GLYCIDOL

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GLYCIDOL	ICSC: 0159 (October 2005)
2,3-Epoxy-1-propanol Oxirane methanol 3-Hydroxypropylene oxide

CAS #: 556-52-5

UN #: 2810

EC Number: 209-128-3

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Above 72°C explosive vapour/air mixtures may be formed.	NO open flames. NO contact with incompatible substances. See Chemical Dangers. Above 72°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

AVOID ALL CONTACT! AVOID EXPOSURE OF (PREGNANT) WOMEN!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat. Dizziness. Drowsiness.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! Redness.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes	Redness. Pain.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal pain. Diarrhoea. Nausea. Vomiting.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable glass or mild steel containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Store only if stabilized. Cool. Dry. Well closed. Ventilation along the floor. Separated from strong bases, strong acids and food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

GLYCIDOL

ICSC: 0159

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS SLIGHTLY VISCOUS LIQUID. Physical dangers Chemical dangers The substance may polymerize. Decomposes on contact with strong acids, strong bases, metal salts or metals. This generates fire and explosion hazard. Attacks plastics and rubber.	Formula: C₃H₆O₂ Molecular mass: 74.1 Decomposes at 166°C Melting point: -45°C Relative density (water = 1): 1.1 Solubility in water: miscible Vapour pressure, Pa at 25°C: 120 Relative vapour density (air = 1): 2.15 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0 Flash point: 72°C c.c. Auto-ignition temperature: 415°C Octanol/water partition coefficient as log Pow: -0.95

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS SLIGHTLY VISCOUS LIQUID.

Physical dangers

Chemical dangers
The substance may polymerize. Decomposes on contact with strong acids, strong bases, metal salts or metals. This generates fire and explosion hazard. Attacks plastics and rubber.

Formula: C₃H₆O₂
Molecular mass: 74.1
Decomposes at 166°C
Melting point: -45°C
Relative density (water = 1): 1.1
Solubility in water: miscible
Vapour pressure, Pa at 25°C: 120
Relative vapour density (air = 1): 2.15
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 72°C c.c.
Auto-ignition temperature: 415°C
Octanol/water partition coefficient as log Pow: -0.95

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure This substance is probably carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
This substance is probably carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 2 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans). MAK: skin absorption (H); carcinogen category: 2; germ cell mutagen group: 3A

ENVIRONMENT
Environmental effects from the substance have not been investigated adequately.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Other CAS numbers for the optical active forms are: d-Glycidol CAS 57044-25-4, l-Glycidol CAS 60456-23-7, dl-Glycidol CAS 61915-27-3.

ADDITIONAL INFORMATION

EC Classification
Symbol: T; R: 45-60-21/22-23-36/37/38-68; S: 53-45

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